国产强伦姧在线观看无码,中文字幕99久久亚洲精品,国产精品乱码在线观看,色桃花亚洲天堂视频久久,日韩精品无码观看视频免费

      上海博耀生物科技有限公司

      當(dāng)前位置:上海博耀生物科技有限公司>>抗體>>標(biāo)記抗體(一抗)>> 流式標(biāo)記Anti-Bcl-xL/BCL2L1/bcl-xs抗體,信號轉(zhuǎn)導(dǎo)抗體原裝現(xiàn)貨

      流式標(biāo)記Anti-Bcl-xL/BCL2L1/bcl-xs抗體,信號轉(zhuǎn)導(dǎo)抗體原裝現(xiàn)貨

      參  考  價:面議
      具體成交價以合同協(xié)議為準(zhǔn)

      產(chǎn)品型號

      品牌

      廠商性質(zhì)經(jīng)銷商

      所在地上海市

      更新時間:2016-03-25 22:46:02瀏覽次數(shù):4518次

      聯(lián)系我時,請告知來自 智能制造網(wǎng)
      中文名稱 Bcl-xL蛋白抗體
      別 名 Apoptosis regulator Bcl X; BclX; Bcl-X; Bcl 2 like 1; Bcl 2 like 1 protein; Bcl xL; BCL X/L; BCL XL/S; Bcl xS; Bcl2 like1; BCL2-related gene; BCL2-related protein, long isofor

       The protein encoded by this gene belongs to the Bcl2 protein family. Bcl2 family members form hetero or homodimers and act as anti or pro apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. Alternative names: Apoptosis regulator Bcl X ; Apoptosis regulator BclX; B cell lymphoma 2 like; Bcl 2 like 1 protein; Bcl X; Bcl xL; BCL XL/S; Bcl xS; Bcl2 Like 1; Bcl2 related gene; BCL2L; Bcl2l1; BCLX; BclXL; BclXs; DKFZp781P2092.

      Function : Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. 
      Isoform Bcl-X(S) promotes apoptosis.

      Subunit : Homodimer. Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Interacts with BCL2L11. Interacts with DMN1L; the interaction stimulates the GTPase activity of DMN1L in synapses and increases the number of axonal mitochondria and the size and number of synaptic vesicle clusters. Interacts with BAD and BBC3. Interacts (isoform Bcl-X(L)) with SIVA1 (isoform 1); the interaction inhibits the anti-apoptotic activity. Interacts with BECN1 and PGAM5. Interacts (isoform Bcl-X(L)) with BAX (isoform Sigma). Isoform Bcl-X(L) interacts with IKZF3. Interacts with HEBP2.
      Subcellular Location : Mitochondrion membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, centrosome. Note=Mitochondrial membranes and perinuclear envelope. Localizes to the centrosome when phosphorylated at Ser-49.
      Tissue Specificity : Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
      Post-translational modifications : Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity. 
      Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during ophase and cytokinesis.

      Similarity : Belongs to the Bcl-2 family.
      Bcl X/L蛋白是Bcl蛋白家族的成員之一,是細胞中抑制細胞凋亡的重要分子之一,Bcl-X/L是結(jié)構(gòu)上與Bcl-2具有43%同源性的蛋白,與Bcl-2的作用相同,可抑制細胞凋亡,在腫瘤的發(fā)生和發(fā)展中起重要作用。

      辣根過氧化物酶標(biāo)記小鼠抗乙肝病毒表面抗原抗體

      辣根過氧化物酶標(biāo)記小鼠抗乙肝病毒表面抗原抗體$r$nHRP標(biāo)記小鼠抗H

      HRP標(biāo)記小鼠抗HBsAg單克隆抗體

      HRP標(biāo)記小鼠抗HBsAg單克隆抗體$r$n乙肝表面抗原抗體

      HRP標(biāo)記小鼠anti-HBsAg單克隆抗體

      HRP標(biāo)記小鼠抗HBsAg單克隆抗體$r$n乙肝表面抗原抗體

      會員登錄

      ×

      請輸入賬號

      請輸入密碼

      =

      請輸驗證碼

      收藏該商鋪

      X
      該信息已收藏!
      標(biāo)簽:
      保存成功

      (空格分隔,最多3個,單個標(biāo)簽最多10個字符)

      常用:

      提示

      X
      您的留言已提交成功!我們將在第一時間回復(fù)您~

      以上信息由企業(yè)自行提供,信息內(nèi)容的真實性、準(zhǔn)確性和合法性由相關(guān)企業(yè)負責(zé),智能制造網(wǎng)對此不承擔(dān)任何保證責(zé)任。

      溫馨提示:為規(guī)避購買風(fēng)險,建議您在購買產(chǎn)品前務(wù)必確認(rèn)供應(yīng)商資質(zhì)及產(chǎn)品質(zhì)量。

      撥打電話
      在線留言