智能制造網(wǎng)>產(chǎn)品庫>其他機(jī)械>其他機(jī)械>其他>>加拿大biomomentumDIC非接觸式quan場應(yīng)變動(dòng)態(tài)測量儀

加拿大biomomentumDIC非接觸式quan場應(yīng)變動(dòng)態(tài)測量儀

參考價(jià)	面議

參考價(jià)

面議

具體成交價(jià)以合同協(xié)議為準(zhǔn)

公司名稱世聯(lián)博研（北京）科技有限公司
品牌
型號(hào)
所在地北京市
廠商性質(zhì)其他
更新時(shí)間2024/5/23 11:34:09
訪問次數(shù)45

產(chǎn)品標(biāo)簽:

在線詢價(jià)收藏產(chǎn)品點(diǎn)擊查看電話

聯(lián)系我們時(shí)請說明是智能制造網(wǎng) 上看到的信息，謝謝!

索取相關(guān)資料

公司介紹主營產(chǎn)品

世聯(lián)博研（北京）科技有限公司（Bio Excellence International Tech Co.,Ltd），簡稱世聯(lián)博研（Bioexcellence），是一家國際前沿生命科學(xué)設(shè)備、耗材、試劑代理銷售與技術(shù)服務(wù)科技企業(yè)，于2010年成立于北京。世聯(lián)博研（Bioexcellence）意即聯(lián)合世界生命科學(xué)界有秀的博士研究生，通過他們向廠商、用戶傳遞專業(yè)、實(shí)效的生命科學(xué)產(chǎn)品與服務(wù)，把包括生物力學(xué)、3D生物打印、再生醫(yī)學(xué)、生物醫(yī)學(xué)工程、微流控&組織器官芯片、細(xì)胞微環(huán)境在內(nèi)的等生命科學(xué)國際前沿產(chǎn)品與技術(shù)引進(jìn)中國，為中國科研學(xué)者提供專業(yè)、實(shí)效的儀器設(shè)備、耗材、試劑以及科研技術(shù)服務(wù)一站式解決方案。世聯(lián)博研有10多年的國際前沿科研儀器代理銷售經(jīng)驗(yàn)，已成功與國際生命科學(xué)領(lǐng)域近50多家的科研產(chǎn)品制造商以及1300多家中國三甲醫(yī)院、2100多家科研院所、600多家高校、400多家檢驗(yàn)檢疫等用戶單位建立了良好誠信的長期合作關(guān)系，正以不斷引進(jìn)國際前沿生命科學(xué)領(lǐng)域科研產(chǎn)品、專業(yè)和規(guī)模化的營銷渠道、高效安quan的國際聯(lián)運(yùn)、快捷的海關(guān)清關(guān)報(bào)關(guān)和專業(yè)人性化售前售后的服務(wù)模式，實(shí)現(xiàn)了國際廠家與中國科研用戶的對(duì)接、落地實(shí)施，實(shí)現(xiàn)合作伙伴資源共享，共同發(fā)展，世聯(lián)博研（Bioexcellence）是個(gè)開放熱情的企業(yè)單位，熱烈歡迎國內(nèi)外相關(guān)單位人士洽談、合作，共謀發(fā)展。世聯(lián)博研業(yè)務(wù)范圍：科研院所單位、生物醫(yī)學(xué)科研高校、醫(yī)院基礎(chǔ)科研單位等。世聯(lián)博研公司代理的品牌具有：1）近10年長期穩(wěn)定的貨源2）以生物力學(xué)、細(xì)胞力學(xué)、生物打印機(jī)、電紡絲、酶聯(lián)斑點(diǎn)分析、細(xì)胞生物分子學(xué)、生物醫(yī)學(xué)組織工程、生物材料學(xué)為主，兼顧其他相關(guān)產(chǎn)品線3）提供專業(yè)產(chǎn)品培訓(xùn)和銷售培訓(xùn)4）良好的技術(shù)支持5）已成交老客戶考證6）每年新增的貨源。

展開顯示更多內(nèi)容

測試儀

產(chǎn)品簡介在線詢價(jià)

mach-1典型功能介紹拉壓扭剪切摩擦穿刺多功能測試不規(guī)則表面自動(dòng)壓痕厚度mapping→3D輪廓測量(三維表面微觀形貌表征)→軟骨質(zhì)量功能流動(dòng)電位評(píng)估摩擦磨損剪切模量測試塔接結(jié)合力粘合力力它能做什么？●以各種模式進(jìn)行壓縮和拉伸測試

加拿大biomomentumDIC非接觸式quan場應(yīng)變動(dòng)態(tài)測量儀產(chǎn)品信息

mach-1典型功能介紹

拉壓扭剪切摩擦穿刺多功能測試
不規(guī)則表面自動(dòng)壓痕厚度mapping→
3D輪廓測量(三維表面微觀形貌表征)→
軟骨質(zhì)量功能流動(dòng)電位評(píng)估
摩擦磨損剪切模量測試
塔接結(jié)合力粘合力
力&電偶聯(lián)測試分析
動(dòng)態(tài)機(jī)械特性測試分析
DIC非接觸式quan場應(yīng)變動(dòng)態(tài)測量
側(cè)限壓縮(confined compression)
耐滲透性測試

生物力學(xué)相關(guān)其他產(chǎn)品

biotester生物材料雙軸測試系統(tǒng)
MicroSquisher多種微力測試分析系統(tǒng)
UniVert單軸拉伸、壓縮和扭力測試分析
Flexcell細(xì)胞拉壓流體剪切培養(yǎng)儀
單層細(xì)胞壓力加載培養(yǎng)與實(shí)時(shí)觀察分析系統(tǒng)
TGT三維血管軟骨皮膚應(yīng)力培養(yǎng)系統(tǒng)
血管生物反應(yīng)器
肌腱韌帶生物反應(yīng)器
軟骨生物反應(yīng)器
旋轉(zhuǎn)灌流生物反應(yīng)器
骨組織灌流表型生物反應(yīng)器
皮膚生物反應(yīng)器
凝膠支架種子細(xì)胞構(gòu)建生物組織系統(tǒng)
皮膚彈性測試分析儀
ITI單層細(xì)胞靜水壓力培養(yǎng)系統(tǒng)
細(xì)胞牽引力顯微鏡
細(xì)胞組織力學(xué)特性定量分析光鑷
離體或活體在體骨參考點(diǎn)壓痕測量分析儀
高通量細(xì)胞力學(xué)特性分析流式細(xì)胞儀
血管血流循環(huán)模擬系統(tǒng)
VCU顱腦損傷儀
三維微流控芯片系統(tǒng)
更多

biomomentum Mach-1 生物力學(xué)形變數(shù)字散斑相關(guān)法測試分析系統(tǒng),生物力學(xué)變形DIC分析系統(tǒng)，生物力學(xué)DIC分析儀，DIC三維場應(yīng)變測量，DIC三維變形測量，生物力學(xué)變形過程中斑點(diǎn)圖案樣本的變形，位移，應(yīng)變和光流測試分析系統(tǒng)

biomomentum Mach-1多功能生物力學(xué)測試系統(tǒng)

該系統(tǒng)是一種高分辨率的微機(jī)械特性測試系統(tǒng)，可用于評(píng)估各種應(yīng)用中生物組織和生物材料的機(jī)械性能。

它能做什么？
●以各種模式進(jìn)行壓縮和拉伸測試，包括：動(dòng)態(tài)，靜態(tài)，應(yīng)力松弛，蠕變，波形加載
●高精度測試，小位移精度
●適合標(biāo)準(zhǔn)的組織培養(yǎng)箱

行程范圍：250毫米
重現(xiàn)性0.01μm
雙向重復(fù)精度±0.1μm
大速度50 mm / s
小速度0.1μm/ s
負(fù)載能力：0.0025mN --- 250N

該系統(tǒng)使用跟蹤和圖像配準(zhǔn)技術(shù)對(duì)樣品在變形過程中的變化進(jìn)行j確的2D和3D測量。這通常用于測量變形過程中斑點(diǎn)圖案樣本的變形，位移，應(yīng)變和光流。

該系統(tǒng)數(shù)字圖像關(guān)聯(lián)（DIC）

數(shù)字圖像相關(guān)（Digital Image Correlation,DIC）也就是數(shù)字圖像相關(guān)方法是一種非接觸式的高精度位移、應(yīng)變測量方法，是目前實(shí)驗(yàn)力學(xué)領(lǐng)域內(nèi)有應(yīng)用前景的測量方法。測量quan場應(yīng)變廣泛應(yīng)用于組織材料力學(xué)、斷裂力學(xué)、微觀納米應(yīng)變測量、各種新型材料測量等。該測量具有非接觸性、應(yīng)用廣泛、精度較高、quan場測量、數(shù)據(jù)采集簡單、測量環(huán)境要求不高、易于實(shí)現(xiàn)自動(dòng)化等優(yōu)點(diǎn)，可以測量微米甚至納米的變形。是一種對(duì)材料或者結(jié)構(gòu)表面在外載荷或其他因素作用下進(jìn)行場位移和應(yīng)變分析的新的實(shí)驗(yàn)力學(xué)方法。目前DIC技術(shù)已經(jīng)在電子封裝、材料測試、斷裂力學(xué)、航空航天、生物力學(xué)以及顯微測量等眾多領(lǐng)域得到應(yīng)用，取得了矚目的成就

數(shù)字圖像相關(guān)性（DIC）是一種光學(xué)方法，它使用跟蹤和圖像配準(zhǔn)技術(shù)對(duì)樣品在變形過程中的變化進(jìn)行j確的2D和3D測量。這通常用于測量變形過程中斑點(diǎn)圖案樣本的變形，位移，應(yīng)變和光流。

典型文獻(xiàn)：

Articulation-Induced Responses of Superficial Zone Chondrocytes in Human Knee Articular Cartilage - Effects of Shear and Sliding

Hsu FH, Hui AY, Chen AC, Lotz MK and Sah R

Orthopeadic Research Society Annual Meeting in Las Vegas, Abstract 0256

Introduction: During daily physical activities, joint articulation results in 3-10% compression in its overall thickness. There is also consensus that articulation is a combined process of shearing and sliding, with relative rotational and translational motions between femoral condyle and tibia cartilage at least at the millimeter scale 2,3. The macroscale motions in the joint which translates to microscale tissue deformation have been assessed in vitro to range from 2.8 to 41.0% depending on the tissue state and lubrication 4 . Biologically, dynamic shear at small amplitudes (±3%) markedly stimulates PRG4 secretion by immature bovine cartilage disks, but little evidence has been provided for similar effects in human cartilage, perhaps due to insufficiently large amplitudes of stimulation 5 . A prior study on the effects of torsional shear on chondrocyte apoptosis has suggested that superficial zone (SZ) cell apoptosis occurs in bovine explants when sheared without lubrication 6 . However, it is unknown whether (1) the degree of SZ cell death and amount of PRG4 secretion is a function of shear and sliding amplitudes and (2) how much resultant tissue deformation and sliding occurs during the chosen method of shear. Therefore, the hypothesis for this study was that articulation induces an amplitude-dependent effect on cartilage superficial zone health and responses, and that the variations in responses are due in part to the extent of tissue shear. Thus, the aims were to assess the effects of graded levels of articulation on chondrocyte viability and PRG4 secretion, and to relate these biological responses to the level of tissue shear.

Methods: A total of 25 human articular cartilage disks (2mm diameter, 1.1mm thick) were harvested from the patellofemoral groove of each of 9 cadaveric knees of donors spanning a wide age range [n=3 Young (<30 yrs), 19, 26 and 29 yrs; n=6 Old (>50yrs), 51, 54, 55, 61, 64, and 66 yrs] without evidence of osteoarthritis; the samples were prepared to include the articular surface, and from regions of tissue with a macroscopically intact articular surface. Disks were incubated in medium supplemented with 10% FBS and 25 ?g/ml ascorbate. On day 3-5, some disks were subjected to mechanical articulation at Low, Mid, or High amplitudes, and others left free-swelling (None). Immediately after treatment, some disks were analyzed for chondrocyte viability at the articular surface. Other disks were incubated for two additional days to assess effects of Low and High articulation on subsequent PRG4 secretion. Some of the donor-matched disks were analyzed mechanically to assess the effects of Mid and High articulation on shear strain and shear stress. Mechanical stimulation. Articulation was implemented at sliding amplitudes of ±100?m, ±500?m, or ±1000?m using a sinusoidal 1Hz waveform in order to simulate effects of Low, Mid, or High levels, respectively. The articulation was imposed for 400 cycles and superimposed upon 20% static compression using a Mach-1 mechanical tester (Biomomentum) with a surface-finished polysulfone platen for articulation against the articular surface 7 and a roughened surface and trough to stabilize the deep cartilage surface. Multi-axial load was recorded. Other disks were maintained free-swelling (None) to serve as control. SZ cell viability analysis. Disks were stained with Live/Dead® (Invitrogen) immediately after treatment, and en face images of the disks were taken at 10x magnification with a fluorescent microscope. The resulting live and dead images were analyzed using a custom image-processing program to determine the number and percentages of live and dead cells. PRG4 protein secretion.. Conditioned medium, collected during the two days of incubation after articulation, was analyzed for PRG4 by ELISA. Biomechanical analysis of tissue shear. The response of cartilage disks was then assessed by video analysis. Videos were recorded with a Nikon D90 SLR digital camera, fitted with a macro lens, and frames analyzed for disk and platen position to determine shear deformation during imposed articulation. Statistics. Summary statistics are presented as mean ± SEM, with n = # of cartilage disks per experimental condition per donor knee, and m = # of donors, so that n*m = total cartilage disks per condition. Data that ranged over an order of magnitude were log10 (1+Y) transformed and percentage data were arc sine transformed prior to statistical analyses to improve normality and homoscedasticity. The effects of mechanical treatment on SZ cell death was assessed by 1-way ANOVA and post-hoc Tukey test. Linear regression of both maximum shear stress and strain to cell death were performed. The effects of age and mechanical stimulus on cartilage PRG4 secretion were assessed by 2-way ANOVA with donor as a random factor.

Results: Articulation induced chondrocyte death in the superficial zone in an amplitude-dependent manner (Fig. 1). In control samples and those subjected to Low articulation, SZ cell viability was high at 90-95%. Mid and high amplitudes of applied articulation resulted in a reduction of viability by 20-25% (p<0.01). Cartilage PRG4 secretion was modulated by age group (p <0.001) and articulation stimulus (p<0.001) in an interactive manner (p<0.01, Fig. 2). In the absence of applied mechanical stimulation, PRG4 secretion by cartilage from young donors was higher (+4.7 ?g/(cm2?day), p<0.05) than that of old donors. With mechanical stimulation, higher articulation resulted in higher PRG4 secretion (+4.0 and +6.8 ?g/(cm2?day), respectively, for low and high articulation) in young donors, but did not have a discernible effect on cartilage from old donors (-0.04 and -0.4 ?g/(cm2?day), for low and high shear, respectively). Cell death and cartilage PRG4 secretion responses were associated with donor-specific tissue mechanics ( Fig. 3 ). Positively correlations were found between cell death and shear stress (Fig. 3A & C, p<0.05) as well as PRG4 secretion and shear strain (p<0.05). Trends were observed between cell death and high shear strain, but were not significant (Fig.3B, p=0.10).

Discussion: The finding that high levels of cartilage shear stress and/or strain can lead to cell death suggests the susceptibility of cartilage to states when lubrication is deficient and/or tissue asperities lead to high articulation-induced tissue shear. On the other hand, the stimulated PRG4 secretion response suggests that the remaining cells can exhibit a feedback response, attempting to counter the excessive shear, as suggested previously 5 . The correlation of biological effects with tissue-specific biomechanical properties suggests that age-related variations in human articular cartilage properties could be involved in variations in mechanobiology. The lack of mechanical responsiveness of human articular cartilage with aging may contribute to the increased incidence of osteoarthritis with aging.

Significance: The susceptibility of articular cartilage to shear-induced cell death suggests that mechanical protection strategies may be helpful to prevent subsequent development of osteoarthritis. Further understanding of the mechanobiological alteration of human cartilage with aging may involve both mechanical properties of the tissue matrix as well as biological variations in the chondrocytes.